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Asbestos and Mesothelioma

Asbestos cancer, also known as mesothelioma is caused by asbestos exposure, typically found in particular asbestos jobsites. Mesothelioma found in those working at particular jobsites such as shipyards can quite often be easily traced to the asbestos products that were present in these locations. For instance, a navy veteran diagnosed with mesothelioma could have worked at Brooklyn Navy Yard outside New York or Todd Shipyards in New York City or California where they came into contact with various products containing asbestos materials. We have an extensive lists of mesothelioma shipyards and mesothelioma jobsites within our site.

Mesothelioma Fact Sheet

Mesothelioma is a rare form of cancer that involves the mesothelium, or cells that line an organ, usually the lungs, abdominal organs, and heart. The most common form of mesothelioma is pleural mesothelioma, where malignant tumors form on the pleura, the sac that lines the chest cavity and protects the lungs. Other forms of mesothelioma affect the peritoneum (abdominal cavity lining) and the pericardium (lining around the heart).¹

Mesothelioma is usually caused by asbestos exposure; 70-80% of all cases reported had workplace exposure. Asbestos is a fibrous mineral known to be carcinogenic. People who are exposed to asbestos fibers for just a short period of time (few weeks) or even to a small amount may be at risk. In particular, people working with asbestos and their family members or those who live with them are more likely to develop mesothelioma.²
Mesothelioma is uncommon, though no longer rare. In 2004, the age-adjusted incidence rate for it was 1.1 per 100,000 persons. Though low, this rate has increased 84% since 1977.³
There are about 2,000 to 3,000 new cases of mesothelioma diagnosed in the US each year.⁴
Men are affected by mesothelioma five times as often as women. The disease rarely appears in those under 55 years of age. Three quarters of those with mesothelioma are over 65 years of age.⁵
There is a long latency period between initial exposure to asbestos and the development of malignant tumors, 35-50 years may elapse before the onset of symptoms.⁶
The early symptoms of mesothelioma can resemble pneumonia, including shortness of breath, difficulty breathing, persistent cough, and chest and abdominal pain. Often, there is fluid buildup between the pleura and chest cavity (called pleural effusions), which leads to dyspnea (shortness of breath) and sometimes pain. Some people may not have any symptoms.
Treatment for mesothelioma can include surgery to remove the tumors, chemotherapy, radiation, or a combination of the three.⁷ A healthcare provider and the patient will determine which is best.

Mesothelioma: Questions and Answers

Mesothelioma is a rare form of cancer in which malignant (cancerous) cells are found in the mesothelium, a protective sac that covers most of the body's internal organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles.

1.What is the mesothelium?

The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.

The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.

2.What is mesothelioma?

Mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to other parts of the body. Most cases of mesothelioma begin in the pleura or peritoneum.

3.How common is mesothelioma?

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. About 2,000 new cases of mesothelioma are diagnosed in the United States each year. Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age.

4.What are the risk factors for mesothelioma?

Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.

Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.

Smoking does not appear to increase the risk of mesothelioma. However, the combination of smoking and asbestos exposure significantly increases a person's risk of developing cancer of the air passageways in the lung.

5.Who is at increased risk for developing mesothelioma?

Asbestos has been mined and used commercially since the late 1800s. Its use greatly increased during World War II. Since the early 1940s, millions of American workers have been exposed to asbestos dust. Initially, the risks associated with asbestos exposure were not known. However, an increased risk of developing mesothelioma was later found among shipyard workers, people who work in asbestos mines and mills, producers of asbestos products, workers in the heating and construction industries, and other tradespeople. Today, the U.S. Occupational Safety and Health Administration (OSHA) sets limits for acceptable levels of asbestos exposure in the workplace. People who work with asbestos wear personal protective equipment to lower their risk of exposure.

The risk of asbestos-related disease increases with heavier exposure to asbestos and longer exposure time. However, some individuals with only brief exposures have developed mesothelioma. On the other hand, not all workers who are heavily exposed develop asbestos-related diseases.

There is some evidence that family members and others living with asbestos workers have an increased risk of developing mesothelioma, and possibly other asbestos-related diseases. This risk may be the result of exposure to asbestos dust brought home on the clothing and hair of asbestos workers. To reduce the chance of exposing family members to asbestos fibers, asbestos workers are usually required to shower and change their clothing before leaving the workplace.

6.What are the symptoms of mesothelioma?

Symptoms of mesothelioma may not appear until 30 to 50 years after exposure to asbestos. Shortness of breath and pain in the chest due to an accumulation of fluid in the pleura are often symptoms of pleural mesothelioma. Symptoms of peritoneal mesothelioma include weight loss and abdominal pain and swelling due to a buildup of fluid in the abdomen. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions. It is important to see a doctor about any of these symptoms. Only a doctor can make a diagnosis.

7.How is mesothelioma diagnosed?

Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.

A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.

If the diagnosis is mesothelioma, the doctor will want to learn the stage (or extent) of the disease. Staging involves more tests in a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan treatment.

Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.

8.How is mesothelioma treated?

Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. Standard treatment options include surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined.

Surgery is a common treatment for mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. For cancer of the pleura (pleural mesothelioma), a lung may be removed in an operation called a pneumonectomy. Sometimes part of the diaphragm, the muscle below the lungs that helps with breathing, is also removed.

Radiation therapy, also called radiotherapy, involves the use of high-energy rays to kill cancer cells and shrink tumors. Radiation therapy affects the cancer cells only in the treated area. The radiation may come from a machine (external radiation) or from putting materials that produce radiation through thin plastic tubes into the area where the cancer cells are found (internal radiation therapy).

Chemotherapy is the use of anticancer drugs to kill cancer cells throughout the body. Most drugs used to treat mesothelioma are given by injection into a vein (intravenous, or IV). Doctors are also studying the effectiveness of putting chemotherapy directly into the chest or abdomen (intracavitary chemotherapy).

To relieve symptoms and control pain, the doctor may use a needle or a thin tube to drain fluid that has built up in the chest or abdomen. The procedure for removing fluid from the chest is called thoracentesis. Removal of fluid from the abdomen is called paracentesis. Drugs may be given through a tube in the chest to prevent more fluid from accumulating. Radiation therapy and surgery may also be helpful in relieving symptoms.

9.Are new treatments for mesothelioma being studied?

Yes. Because mesothelioma is very hard to control, the National Cancer Institute (NCI) is sponsoring clinical trials (research studies with people) that are designed to find new treatments and better ways to use current treatments. Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease. Participation in clinical trials is an important treatment option for many patients with mesothelioma.

People interested in taking part in a clinical trial should talk with their doctor. Information about clinical trials is available from the Cancer Information Service (CIS) (see below) at 1–800–4–CANCER. Information specialists at the CIS use PDQ®, NCI's cancer information database, to identify and provide detailed information about specific ongoing clinical trials. Patients also have the option of searching for clinical trials on their own. The clinical trials page on the NCI's Cancer.gov Web site, located at http://www.cancer.gov/clinicaltrials on the Internet, provides general information about clinical trials and links to PDQ.

People considering clinical trials may be interested in the NCI booklet Taking Part in Cancer Treatment Research Studies. This booklet describes how research studies are carried out and explains their possible benefits and risks. The booklet is available by calling the CIS, or from the NCI Publications Locator Web site at http://www.cancer.gov/publications on the Internet.

Mesothelioma

Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the pericardium (a sac that surrounds the heart) or tunica vaginalis.

Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos. Unlike lung cancer, there is no association between mesothelioma and smoking.[1] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).

The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.

What is mesothelioma?

Mesothelioma is a form of cancer affecting the abdominal cavity, chest cavity, and the region surrounding the heart. Due to its uncommon nature, mesothelioma is typically difficult to diagnose and treat. It has been connected with exposure to asbestos, a material formerly present in many work environments. Only about 3,000 individuals are diagnosed annually.

Individuals with a history of extended asbestos exposure are at the highest risk for developing malignant mesothelioma. Even a small exposure to this cancer-causing material can result in malignant mesothelioma. However, mesothelioma has a latency of up to thirty-forty years, and many individuals previously exposed to asbestos are now displaying symptoms. This means the average age of mesothelioma patients is between 50 and 70 years. Men are typically affected more, due to the common presence of asbestos in industrial settings. There are three major types of malignant mesothelioma . epithelial, sarcomatoid, and mixed. Epithelial mesothelioma is most common. Symptoms may include, but are not limited to respiratory distress, a lasting cough, and pneumonia. In addition, symptoms are often mistaken for less serious ailments, and many patients do not show any signs at all.

Individuals with pleural mesothelioma may accumulate some fluid between the lung lining and chest cavity. This can be detected through a chest x-ray, as well as CT scans.

Diagnosis of Mesothelioma is based on a pathological exam, more commonly referred to as a biopsy. This exam will test a tissue sample for the presence of malignant and/or pleural mesothelioma.

Mesothelioma Source is dedicated to providing victims and their families with the latest Mesothelioma news and information. Even though this is a relatively rare disease, it can affect thousands of families each year. If you or one of your loved ones would like more information, please don't hesitate to request a free information packet.

Asbestos as the Primary Cause of Mesothelioma
Asbestos is a type of insulation material, which was used widely in the past in the following industries:

Construction industry
Ship building industry
Automotive industry
Other manufacturing industries
Mesothelioma occurred most often in persons who worked in the above industries and were exposed to asbestos in their workplace. The use of asbestos was very widespread after 1945. However, first symptoms of mesothelioma may not become apparent 10-40 years after the initial exposure, which makes it very hard to diagnose. The peak in mesothelioma cases is expected to be reached around 2010 according to some studies. There are three most commonly used types of asbestos: white, brown, and blue. Brown and blue asbestos are most commonly associated with mesothelioma. These types of asbestos have been banned by most countries in the 1990s.

Asbestos is a very dangerous substance and can cause a lot of damage to your health. It is made up of very small fibers, which can find their way to pleura (outside lining of the lung) and damage the cells pleura is made of. These fibers can also be carried on clothing, which makes them dangerous not only to the person exposed to asbestos, but to their family members as well.

Note of Urgency
Mesothelioma is a life-threatening disease and cannot be left untreated. The sooner it is diagnosed the better a patient's chances are of fighting this deadly cancer. Please contact a qualified physician immediately if you or someone you know has been diagnosed with mesothelioma.

Mesothelioma Treatment Options

Mesothelioma treatment is critical when a mesothelioma diagnosis occurs. Throughout our site, you'll find lists of mesothelioma hospitals and mesothelioma treatment centers. You'll also find information about mesothelioma doctors such as Dr. Sugarbaker, a mesothelioma expert. New Mesothelioma drugs and mesothelioma treatments, such as Alimta are being used to fight mesothelioma lung cancer. A mesothelioma biopsy is often used to determine if a loved one is affected. If you or a loved one may be facing the reality that mesothelioma cancer treatment is necessary, fill out our form to receive the latest treatment options and mesothelioma clinical trials information.